Can Alcohol Kill You?—Let’s Count the Ways

According to the World Health organisation, alcohol kills more than 3 million people worldwide each year, which translates to one person every 10 seconds. That’s more than the amount of people lost to AIDS, tuberculosis, and violence. The statistic includes alcohol-related driving fatalities, violence, and health issues arising from excessive alcohol consumption. Because alcohol is legal in most countries, and because—especially in the US and western culture in general—it is promoted in advertising and glamorised in film, its dangers are often minimised or disregarded by young people, and the warnings about problem-drinking and its consequences are viewed as the admonitions of uptight grownups. Unfortunately, the facts support the admonitions. So, how can alcohol kill you?

Here are a few ways it can—and does—end lives: Drunk driving accounted for ten thousand deaths in 2010—that was over thirty percent of all traffic fatalities. Acute alcohol poisoning kills over one thousand people each year. Nearly sixteen thousand people died in 2010 from alcohol-induced liver disease. Over fifty percent of people who die in fires have high blood-alcohol levels. One quarter of all emergency room admissions, one-third of all suicides and more than half of all homicides and incidents of domestic violence are alcohol related. Unintentional injuries related to alcohol consumption cause over eighteen hundred deaths each year among college students. Health problems, including increased likelihood of stroke, diabetes, cirrhosis of the liver, oesophageal cancer, and compromised immune system can lead, if untreated, to premature death. Alcohol in combination with other drugs, especially pain medications, tranquillisers, and sleep medications, can cause death by slowing down respiration as well as by causing the aspiration of vomit. The simple fact is that alcohol impairs judgment, cognition, inhibitions regarding excessive risk-taking and acting out of aggressive tendencies, and other faculties that reduce the likelihood of accident or death. If alcohol consumption becomes regular, increases over time, or increases in amount, or if consequences of drinking are accumulating, treatment is indicated, because yes, alcohol can kill you. 

Bill Wilson is on record for having found a solution in 1960 for treating anxiety and depression

 Bill Wilson is on record for having found a solution in 1960 for treating anxiety and depression using vitamin B-3 therapy and worked tirelessly for eleven years begging for its inclusion into A.A. recovery circles.  His desire was to help alcoholics stay recovered. This means he would have immediately brought this mineral replacement therapy that eliminates alcohol cravings forth without exception.  Master of ceremonies, Andrew W. Saul, includes Bill Wilson as an inductee of the Orthomolecular Medicine Hall of Fame at the Hotel Vancouver, British Columbia, Canada, April 29, 2006 in his induction speech, “…To this day, selective history records A.A.’s 12-Step Program, but has forgotten, or deliberately purged, what Bill wanted to be A.A.’s 13th step – orthomolecular therapy with vitamin B3.”[Lee Brack1]  In February 2009, Orthomolecular Medicine’s founder, Abram Hoffer and Bill Wilson’s good friend, clarified to me over the phone, “..yes, Lee, he wanted to share this information as an added step and talked about it all the time because he felt so strongly about nutrition…”  Abram Hoffer passed away a few months later in May having lived healthy and happily for ninety one and a half years.

6 April 2013 Tuned-In Centre, Majuba Road, Redcar, TS10 5BJ

Event	North-West District of Cocaine Anonymous welcomes you to... Reaching Out in Redcar UNITY Day
Time	Saturday 11:30am Start
Address	Tuned-In Centre, Majuba Road, Redcar, TS10 5BJ
Additional Notes	Speakers; Cameron F (Canada)  Will B (Spain) Danielle (Cheshire)
Information	TICKETS £5 (or donation). Refreshments provided. Click here to download flyer & contact info.

Understand the inherently peaceful presence of Awareness the art of Living in the NOW

Understand the inherently peaceful presence of Awareness the art of Living in the NOW, and see that this peace is not dependent upon the condition of the mind, body or world, just as a screen is not dependent on the quality of the words or images that appear on it.

The addicted brain is distinctly different from the nonaddicted brain, as manifested by changes in brain metabolic activity, receptor availability, gene expression, and responsiveness to environmental cues

There are many biological factors that are involved with the addicted brain. "The addicted brain is distinctly different from the nonaddicted brain, as manifested by changes in brain metabolic activity, receptor availability, gene expression, and responsiveness to environmental cues" (2) In the brain, there are many changes that take place when drugs enter a person's blood stream. The pathway in the brain that the drugs take is first to the ventral tegmentum to the nucleus accumbens, and the drugs also go to the limbic system and the orbitofrontal cortex, which is called the mesolimbic reward system. The activation of this reward system seems to be the common element in what hooks drug users on drugs (2).

Drugs seem to cause surges in dopamine neurotransmitters and other pleasure brain messengers. However, the brain quickly adapts and these circuits desensitize, which allows for withdrawal symptoms to occur (3). Drug addiction works on some of the same neurobiological mechanisms that aid in learning and memories (3). "This new view of dopamine as an aid to learning rather than a pleasure mediator may help explain why many addictive drugs, which unleash massive surges of the neurotransmitter in the brain, can drive continued use without producing pleasure-as when cocaine addicts continue to take hits long after the euphoric effects of the drug have worn off or when smokers smoke after cigarettes become distasteful." (4)

Since memory and pleasure zones are intertwined in the brain, many researchers have been using psychological approaches to stop drug use. Many rehabilitation centers have used classical conditioning to rehabilitate drug addicts. They combine exposure to drugs combined with cognitive scripts, like statements how drugs have destroyed a person's life or what can be accomplished without using drugs, according to DeLetis (5). By using classical conditioning, the drugs addicts pair the drugs with negative connotations and properties. "Adverse withdrawal symptoms can function as an instrumental negative reinforcer and can be linked to the opponent process theory of motivation." (6) However, drug addicts may relapse and start using again because of many environmental "cues", which are external forces that are associated with drug use in their lives. When the drugs addicts see these cues, their brain circuitry, especially the orbitofrontal cortex become hyperactive and causes these people to start craving drugs again (2). No matter how successful the rehabilitation treatment is, once those "cues" are around, the drug addicts remember how pleasurable the drugs felt and relapse into drug abuse again.

Through all of the research done about drug addiction and its affects on the brain, one can see how drug addiction is considered a brain disease. Drug addiction is a disabling disease and can ruin a person's life. By taking drugs, a person's brain becomes "rewired" to tolerate high amounts of dopamine neurotransmitters, but once those high amounts of dopamine cease to exist, the person experiences withdrawal symptoms. However, there are ways drug addicts can control their drug intake by using classical conditioning techniques, which allows them to associate drugs with negative attributes.

Bill Wilson is on record for having found a solution in 1960 for treating anxiety and depression using vitamin B-3 therapy and worked tirelessly for eleven years begging for its inclusion into A.A. recovery circles.

The Serotonin Support Group (SSG)

Is a mutual support group for people who suffer from low Serotonin levels,  wishing to participate in a support group that uses as one method a vitamin supplement as a method of replacement or addition to a diet to help the sufferer.The historical basis of this form of nutritional treatment was discovered and researched by Bill Wilson of Alcoholics Anonymous and it is to promote this Legacy to persons who suffer from low serotonin uptake and depression that the Group was formed.Bill Wilson wished to add a step to the 12 he had produced for AA. We struggle to make that possible and fulfill his promise. Without detracting from the message of recovery in the twelve steps of Alcoholics Anonymous. If alcoholics and addictive abusers of other drugs have specific chemical imbalances in the brain, and if these imbalances turn out to be reliable enough and measurable enough in sufficiently large numbers of human addicts, it is natural to wonder whether, eventually, science can find a way to correct them.

Some sort of neurotransmitter cocktail, maybe.

Or just possibly... a pill?

Bill Wilson is on record for having found a solution in 1960 for treating anxiety and depression using vitamin B-3 therapy and worked tirelessly for eleven years begging for its inclusion into A.A. recovery circles.  His desire was to help alcoholics stay recovered. This means he would have immediately brought this mineral replacement therapy that eliminates alcohol cravings forth without exception. Andrew W. Saul, includes Bill Wilson as an inductee of the Orthomolecular Medicine Hall of Fame at the Hotel Vancouver, British Columbia, Canada, April 29, 2006 in his induction speech, “…To this day, selective history records A.A.’s 12-Step Program, but has forgotten, or deliberately purged, what Bill wanted to be A.A.’s 13th step – orthomolecular therapy with vitamin B3.”[Lee Brack1]  In February 2009, Orthomolecular Medicine’s founder, Abram Hoffer and Bill Wilson’s good friend, clarified to me over the phone, “..yes, Lee, he wanted to share this information as an added step and talked about it all the time because he felt so strongly about nutrition…”  Abram Hoffer passed away a few months later in May having lived healthy and happily for ninety one and a half years.

The results strongly suggest that the mechanism of depression after alcohol drinking may be related to serotonin.

We examined tryptophan and serotonin (5-hydroxytryptamine) levels in the blood after consumption of alcohol. Forty-five minutes after drinking, whole blood serotonin concentration was significantly reduced, whereas no changes were observed in tryptophan level. The diurnal rhythm of 5-HT in subjects who the day before had drunk alcohol was quite different from the control group, but very similar to that of patients with depression. The results strongly suggest that the mechanism of depression after alcohol drinking may be related to serotonin.

 

The important thing with serotonin, is to keep it at steady levels.

The important thing with serotonin, is to keep it at steady levels. The medicines that raise the level of serotonin in the brain do so by slowing the reabsorbtion of serotonin. The alcohol increases the availible serotonin for a bit and then it drops off quickly, leaving the depressed person feeling worse, and they tend to not take the medicine correctly when they feel badly or are drunk. High serotonin levels do not mean somebody will feel happy or good, It makes it more likely that they won't feel realy bad.

Ms Sandiford to be executed for drug trafficking.

A British grandmother has been sentenced to death by firing squad for smuggling almost 5kg of cocaine into Bali.

Lindsay Sandiford was arrested in May last year after she tried to enter the Indonesian holiday island with illegal drugs worth £1.6 million hidden in her suitcase.

Local prosecutors had called for the 56-year-old housewife to be jailed for 15 years. But today there were gasps in the Bali courtroom when a panel of judges announced Ms Sandiford would be executed for drug trafficking.

As the shock verdict was announced, Ms Sandiford, from Gloucestershire, slumped back in her chair in tears before hiding her face with a brown sarong as she was led out of the courtroom.

Merry Christmas

Emotional eating is when people use food as a way to deal with feelings instead of to satisfy hunger. We've all been there, finishing a whole bag of chips out of boredom or downing cookie after cookie while cramming for a big test. But when done a lot — especially without realizing it — emotional eating can affect weight, health, and overall well-being.

Not many of us make the connection between eating and our feelings. But understanding what drives emotional eating can help people take steps to change it.

One of the biggest myths about emotional eating is that it's prompted by negative feelings. Yes, people often turn to food when they're stressed out, lonely, sad, anxious, or bored. But emotional eating can be linked to positive feelings too, like the romance of sharing dessert on Valentine's Day or the celebration of a holiday feast.

Sometimes emotional eating is tied to major life events, like a death or a divorce. More often, though, it's the countless little daily stresses that cause someone to seek comfort or distraction in food.

Emotional eating patterns can be learned: A child who is given candy after a big achievement may grow up using candy as a reward for a job well done. A kid who is given cookies as a way to stop crying may learn to link cookies with comfort.

It's not easy to "unlearn" patterns of emotional eating. But it is possible. And it starts with an awareness of what's going on.

ARE YOU ADDICTED TO BUSYNESS ARE YOU A SOCIAL MEDIA ADDICT

You may be lost in the addiction to busyness if…

• Your usual response to “how are you?” is “so busy”, “crazy busy” or “busy but good”
• You spend time worrying about how busy you are going to be tomorrow
• You get angry when your spouse or friends aren’t as busy as you
• Your busy life keeps you up at night thinking about everything you didn’t get done
• You make a point of letting people know that you stay at the office after hours
• You check email several times a day
• You zone out during conversations thinking about everything you have to do
• You volunteer for things you don’t care about
• You spend time complaining about how busy you are
• You make list after list to make sure you don’t forget anything during your busy day
• You allocate time each day to clean your desk or organize your stuff
• You regularly eat in your car
• You use a phone in the car because “it’s the only time you have to talk”

experts believe we can actually become "addicted" to stress.

Stress can be physical,And then there’s the kind that’s in our heads — that OMG I’m so overwhelmed right now feeling. While psychological stress has some definite downsides (chronic freak-outs may increase our risk for cancer and other diseases), take a moment to exhale. In moderate amounts, stress can boost our focus, energy, and even our powers of intuition.

Still, in some cases, stress does more than light a productivity-boosting fire under our butts. Both emotional and physical stress activate our central nervous system, causing a “natural high,” says Concordia University neuroscientist and addiction specialist Jim Pfaus. “By activating our arousal and attention systems,” Pfaus says, “stressors can also wake up the neural circuitry underlying wanting and craving — just like drugs do.”

This may be why, experts believe, some of us come to like stress a little too much.

Type A and Type D personalities — or people prone to competitiveness, anxiety, and depression — may be most likely to get a high from stressful situations, says stress management specialist Debbie Mandel. Stress “addicts,” Mandel says, “may also be using endless to-do lists to avoid less-easy-to-itemize problems — feelings of inadequacy, family conflicts, or other unresolved personal issues.”

Some stress junkies have difficulty listening to others, concentrating, and even sleeping because they can’t put tomorrow’s agenda out of their minds, explains Mandel. Others tend to use exaggerated vocabulary — craaazy busy right now, workload’s insane!! And some begin to feel anxious at the mere thought of slowing down their schedule.

But psychologist and addiction researcher Stanton Peele cautions against labeling anyone a stress addict. “Only when that pursuit of stress has a significant negative impact on your life could it qualify as addiction,” he said, adding that many people are able to effectively manage — and in fact thrive under — high stress conditions. (Think: Olympic athletes or President Obama.)

 Study: Stress Shrinks the Brain and Lowers Our Ability to Cope with Adversity

For budding stress “addicts” or for those who just, well, feel overwhelmed, here are some tips to dial down that anxiety:

• Seek professional help if you’re verging on burnout. (Not only can hashing it out with a therapist take a load off your mind. Some studies suggest it also boosts physical fitness.)
• Do something creative. Mandel recommends carving out a once-weekly time not to think about tomorrow’s agenda by painting, cooking, writing, dancing, or anything else that’ll take you off the clock temporarily.
• Take it outside. Numerous studies show spending time in nature improves general well-being, lowers anxiety, stress and depression, and even boosts self-confidence. Especially for women. (As it turns out, most addiction recovery centers offer outdoor-immersion programs.)
• Calm down quickly. If you really don’t have time for any of the above, these 40 tricks to chill take five minutes or less.

Some of us may seek out stress a bit more excessively than others and struggle to just relax. It takes skill to handle hectic agendas and long lists of responsibilities — without losing sleep or feeling frazzled. So try these tips and try not to freak out.

Worried that you or someone you know seeks out stress a little too much? Think stress addiction is a myth? Tell us about it in the comments section below.

For those red wine drinkers who’ve been feeling morally superior about all the health benefits of the relaxing glass or two sipped during dinner, there’s some bad news on the horizon.

 Turns out, those glasses of wine would be a lot healthier if they were non-alcoholic, a new study shows.  Spanish researchers led by Gemma Chiva-Blanch of the University of Barcelona found that non-alcoholic red wine reduced blood pressure in men at high risk for heart disease better than standard red wine or gin, according to the study published in the American Heart Association journal Circulation Research. Although the reduction in both systolic and diastolic blood pressure was modest, decreases of just 4 and 2 mm Hg have been associated with a 14 to 20 percent reduction in heart disease and stroke, the researchers pointed out. “The daily consumption of dealcoholized red wine could be useful for the prevention of low to moderate hypertension,” they concluded.  Although there have been many studies on the impact of moderate drinking on health, the findings have been mixed, with some studies showing a benefit and others suggesting none. The new study found that 3 ounces of gin a day had no impact on blood pressure, while consumption of regular red wine led to a small, but not statistically significant, improvement. The new study suggests that if you’re going to have a drink, red wine would be the healthiest choice, said Dr. Kelly Anne Spratt, a heart disease prevention specialist and a clinical associate professor of medicine at the University of Pennsylvania. Still, Spratt said, “while there are those of us in cardiology who believe in the benefits of red wine, we want to be wary. We’re not going like gangbusters recommending people go out and start drinking. There are a lot of problems associated with drinking, like weight gain, cardiomyopathy, alcoholism, an increased breast cancer risk in women who consume two or more drinks a day.” Chiva-Blanch and her colleagues suspect that blood pressure improvements were due to the impact of polyphenols, a red wine component, on nitric oxide. The theory is that nitric oxide molecules help blood vessels relax, which allows better flow and more blood to reach the heart and other organs. For the new study, Chiva-Blanch and her colleagues followed 67 men with diabetes or three or more cardiovascular risk factors. During the study, the men were all required to consume the same foods along with one of three drinks: 10 ounces of red wine, 10 ounces of non-alcoholic red wine or 3 ounces of gin. During the 12 week study, the men tried each diet/beverage combination for four weeks at a time. The researchers determined that the standard red wine and its nonalcoholic counterpart contained equal amounts of polyphenols, an antioxidant which has been shown to decrease blood pressure. Men who drank regular red wine saw minor reductions in blood pressure – too small, in fact, to be statistically significant. Those who drank gin with their meals saw no change in blood pressure. But men who drank non-alcoholic red wine saw a blood pressure decrease of about 6 mm Hg in systolic and 2 mm Hg in diastolic blood pressure. Chiva-Blanch and her colleagues concluded that their findings show that the alcohol in red wine actually weakens its ability to lower blood pressure.

Marbella Forest Fire

Dream Warriors Testament: PART 1 ROCK BOTTOM Flash News best selling new addiction book

Dream Warriors Testament:PART 1 ROCK BOTTOM 

Dream Warriors testament, Arriving at a time in my life after thirty years of not drinking to leave an honest account of what it was like, my experience the good and the bad, the addictions of which alcohol was but one, the spiritual experiences and the formation of my personal program.The founding of Narcotics Anonymous in Spain.The trails and tribulations of the battles and failures with the ego.Many people need to remain anonymous within my journal and many may see there rolls differently.The writing is by a dyslexic this is not an excuse but a fact.Without the help of AA,NA,CA,ALANON,OA,SA and CODA this story would have not been possible.Many Angels have appeared in my life and I acknowledge you all.My sponsor and authentic founder of NA Spain remains my confident and long term friend.This person without any thought of reward spent endless time supporting me threw the early years of recovery  and whom I will be eternally grateful.

PART 1 ROCK BOTTOM

Now cast your mind back thirty years.A hopeless drunk is staggering our of a nightclub set in an area known as over the border in a North East English town. The street lights  shimmering off the tarmac rushed towards me as I crumpled into unconsciosness My semicomatse head bouncing off the granite curbstones feeling like a gentle caress. Blackout, oblivion was where my advanced alcoholism always took me. The promise of a wonderous adventure filled illusions had long since disappeared.The idea that I could handle alcohol or drugs had seemed irrelevant the inevitability of my condition overcame me I dimmely felt hands rifleing threw my pockets. Hopelessly drunk I was incapable of doing anything even my bodily functions now took care of themselves. Death, whatever that was, would have been welcomed as yet another phase of insane bingeing ran its course.By know I was starting to understand that once I drank I had no control over the outcome.All the excuses had been used up and I was in utter bewilderment as to why my longtime friend alcohol had turned on me.Where had my friends disappeared to and the conviviality of there happy company.

The answer crashed into my befuddled brain I had used up all there excuses as well as mine and had become the unfunny court jester who continuosly embarrassed them with drunken brawling heaping abuse onto those closest to me as the full reality of my condition became apparent to them all.The witty raconteaur had become the stinking drunk,bloated vomiting and unfunny.In reality I sorted out dark places where people like me sort the company of like minded others.The illegal blues clubs and shebeens the drinking dens for prostitutes and criminals.I could not resist the call to visit once I had, had that first drink.It did not matter what it was for I had long since recognised that if it was a weak shandy or a double whisky the results would be exactly the same.It came as no surprise to be lying in the gutter blacked out.

What did come as a surprise was to be sitting in the back of a taxicab.What had happened had I met with a good Samaritan for they where a rareity in this area of dockland.I was over the years after this to try many times to attempt to rationalise this answer out. Had some golden lady of the night rescued me doubtful but possible or a kindly taxi driver even more improbable.Yet here I was being dropped off outside my front door in a small suburban village.My eyes fearfully scanned the street for what had become the inevitable results of my binges a police car.I thanked the taxi driver and searched for my keys.No police car but now the guilt and remorse the terrible psychical withdrawal from alcohol gripped my being. I must have another drink as my skin started crawling and the stomach wrenching vomit reflex took hold.

It was at this time I recognised that all the lights were on yet there was no one in the house.I stopped I glanced at the red flock wallpaper with the glistening remains of the whisky glass catching the evidential reflection of the lights.Yes this was the right house.There was the drinks cupboard it was open nothing remained. Panic,fear my head whirled a neon red sign shown in my head NO DRINK.No drink nothing.I heard a car drive up my car, my wife.I needed to get what was left of the brain into gear.I wracked my brain for a solution something that would work something that would give one more drink anything.She was on the path give me an idea any idea nothing. The withdrawls were kicking in the shakeing was starting with the first tremors my fingers twitched as the withdrawls started.Its just a hangover.You used the magic word that would start the withdrawl HANGOVER. I didn’t do hangovers anymore I just got sick very sick very quickly.How the hell was I to get a drink I must have a drink.I needed a solution fast any solution.

During experiments on the axons of the Woods Hole squid (loligo pealei), we tested our cockroach leg stimulus protocol on the squid's chromatophores.

 

 The results were both interesting and beautiful. The video is a view through an 8x microscope zoomed in on the dorsal side of the caudal fin of the squid. We used a suction electrode to stimulate the fin nerve. Chromatophores are pigmeted cells that come in 3 colors: Brown, Red, and Yellow. Each chromatophore is lined with up to 16 muscles that contract to reveal their color.

Paloma T. Gonzalez-Bellido of Roger Hanlon's Lab in the Marine Resource Center of the Marine Biological Labs helped us with the preparation. You can read their latest paper at:http://rspb.royalsocietypublishing.org/content/early/2012/08/13/rspb.2012.1374

ADDICTION charity Focus12 has received a huge financial boost after a codumentary about Russell Brand was shown last night.

The documentary Russell Brand: Addiction to Recovery resulted in an immediate boost in donations and inspired the managing director of Bury St Edmunds based Chevington Finance and Leasing to offer the charity £106,000 over three years.

Russell Brand attended Focus12, the Bury St Edmunds abstinence-based alcohol and drug rehabilitation centre, in 2003 and is now a patron of the charity, describing it as ‘a really excellent example of a small cost effective rehab that can help people change in dramatic ways’.

Chip Somers, Focus12’s chief executive, said: “Russell’s documentary and his work this year to raise the profile of abstinence based recovery has got people talking about addiction in a different way, and made them realise that there is a viable alternative to simply giving up on addicts, or parking them on methadone.

“We are blown away by the generosity of Chevington — this financial support will make a huge difference to us as a charity and will certainly mean we can continue to stay open and help those who need us for longer. Raising funds for a recovery charity has never been harder than it is at present, every day is literally a struggle to keep afloat and we are very grateful.”

Clive Morris, Managing Director of Chevington Finance and Leasing said: “My wife and I were incredibly touched by last night’s documentary, which inspired us to endorse the local treatment centre Focus12, and we have today agreed funding assistance for the charity of £106,000 over the next 4 years.

“We believe that as a successful, responsible and reliable company we have a duty to help local charities survive this recession and the work that Chip Somers and his team do is fantastic and we fully endorse their abstinence based programme and have seen what a difference it makes to people’s lives.”

Diabetes drug makes brain cells grow

The widely used diabetes drug metformin comes with a rather unexpected and alluring side effect: it encourages the growth of new neurons in the brain. The study reported in the July 6th issue of Cell Stem Cell, a Cell Press publication, also finds that those neural effects of the drug also make mice smarter. See Also: Health & Medicine Brain Tumor Stem Cells Nervous System Mind & Brain Brain Injury Intelligence Neuroscience Strange Science Reference Neural development Stem cell treatments Diabetes mellitus type 2 Embryonic stem cell The discovery is an important step toward therapies that aim to repair the brain not by introducing new stem cells but rather by spurring those that are already present into action, says the study's lead author Freda Miller of the University of Toronto-affiliated Hospital for Sick Children. The fact that it's a drug that is so widely used and so safe makes the news all that much better. Earlier work by Miller's team highlighted a pathway known as aPKC-CBP for its essential role in telling neural stem cells where and when to differentiate into mature neurons. As it happened, others had found before them that the same pathway is important for the metabolic effects of the drug metformin, but in liver cells. "We put two and two together," Miller says. If metformin activates the CBP pathway in the liver, they thought, maybe it could also do that in neural stem cells of the brain to encourage brain repair. The new evidence lends support to that promising idea in both mouse brains and human cells. Mice taking metformin not only showed an increase in the birth of new neurons, but they were also better able to learn the location of a hidden platform in a standard maze test of spatial learning. While it remains to be seen whether the very popular diabetes drug might already be serving as a brain booster for those who are now taking it, there are already some early hints that it may have cognitive benefits for people with Alzheimer's disease. It had been thought those improvements were the result of better diabetes control, Miller says, but it now appears that metformin may improve Alzheimer's symptoms by enhancing brain repair. Miller says they now hope to test whether metformin might help repair the brains of those who have suffered brain injury due to trauma or radiation therapies for cancer.

Smokers could one day be immunised against nicotine so they gain no pleasure from the habit, according to researchers in the US.

They have devised a vaccine that floods the body with an antibody to assault nicotine entering the body.

A study in mice, published in Science Translational Medicine, showed levels of the chemical in the brain were reduced by 85% after vaccination.

Years of research are still needed before it could be tested on people.

However, lead researcher Prof Ronald Crystal is convinced there will be benefits.

"As far as we can see, the best way to treat chronic nicotine addiction from smoking is to have these Pacman-like antibodies on patrol, clearing the blood as needed before nicotine can have any biological effect."

New approach

Other "smoking vaccines" have been developed that train the immune system to produce antibodies that bind to nicotine - it is the same method used to vaccinate against diseases. The challenge has been to produce enough antibodies to stop the drug entering the brain and delivering its pleasurable hit.

Scientists at Weill Cornell Medical College have used a completely different approach, a gene-therapy vaccine, which they say is more promising.

Continue reading the main story

“Start Quote

If they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit”

Prof Ronald CrystalWeill Cornell Medical College

A genetically modified virus containing the instructions for making nicotine antibodies is used to infect the liver. This turns the organ into a factory producing the antibodies.

The research team compared the amount of nicotine in the brains of normal mice with those that had been immunised. After being injected with nicotine, the vaccinated mice had nicotine levels 85% lower.

It is not known if this could be repeated in humans or if this level of reduction would be enough to help people quit.

Prof Crystal said that if such a vaccine could be developed then people "will know if they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit".

He added: "We are very hopeful that this kind of vaccine strategy can finally help the millions of smokers who have tried to stop, exhausting all the methods on the market today, but find their nicotine addiction to be strong enough to overcome these current approaches."

'Impressive and intriguing'

There are also issues around the safety of gene therapy in humans that will need to be answered.

Professor of genetics at the University of Kent, Darren Griffin, said the findings were "impressive and intriguing with great potential" but cautioned there were still many issues which needed addressing.

He said the main issue "is whether the observed biochemical effects in lab mice genuinely translate to a reduced addiction in humans given that such addictions can be both physical and psychological".

Dr Simon Waddington, from University College London, said: "The technology underpinning gene therapy is improving all the time and it is encouraging to see these preliminary results that indicate it could be used to address nicotine addiction, which is damaging to the nation's health and a drain on the health service economy."

If such a vaccine was developed it could also raise ethical questions about vaccinating people, possibly in childhood, before they even started smoking.